Recent researches show that EDA gene was expressed in the oral epithelial and outer enamel epithelial of murine tooth germ in the cap stage. Mutation of EDA gene would cause the abnormal development of enamel knot. 有研究表明EDA基因在小鼠的口腔上皮以及帽状期牙胚的外釉上皮中表达,EDA基因的突变可引起釉结节的发育异常,推测EDA基因在调控小鼠牙齿的形态发育中占有重要作用。